Summary

Name CCR2
Full Name C-C chemokine receptor type 2
Synonyms C-C CKR-2, CC-CKR-2, CCR-2, CCR2, Monocyte chemoattractant protein 1 receptor, MCP-1-R | CMKBR2
Primary ID P41597
Links - -
Type protein
Relations 4
Pathways Satellite: CCR2
Function Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (PubMed:8146186, PubMed:8048929, PubMed:23408426). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ JAK2up-regulates activity img/direct-activation.png phosphorylation CCR2 0.601
Publications: 1 Organism: Homo Sapiens
+ CCL2up-regulates activity img/direct-activation.png binding CCR2 0.783
Publications: 1 Organism: Homo Sapiens
+ CCL3up-regulates activity img/direct-activation.png binding CCR2 0.55
Publications: 1 Organism: Mus Musculus
+ CCR2up-regulates activity img/direct-activation.png phosphorylation ERK1/2 0.337
Publications: 1 Organism: Mus Musculus