Summary

Name ASIP
Full Name Agouti-signaling protein
Synonyms ASP, Agouti switch protein | AGTI, AGTIL, ASP
Primary ID P42127
Links - -
Type protein
Relations 7
Function Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

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Relations

Regulator Mechanism target score ℹ
+ ASIPdown-regulates activity img/direct_inhibition.png binding MC3R 0.526
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ ASIPdown-regulates activity img/direct_inhibition.png binding MC1R 0.734
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ ASIPup-regulates img/direct-activation.png binding ATRN 0.401
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ ASIPdown-regulates activity img/direct_inhibition.png binding MC5R 0.515
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ ASIPdown-regulates activity img/direct_inhibition.png binding MC4R 0.515
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ ASIPdown-regulates activity img/direct_inhibition.png binding MC2R 0.513
Publications: 1 Organism: Homo Sapiens