3.0
Summary
| Name |  TECView Modifications |
| Full Name | Tyrosine-protein kinase Tec |
| Synonyms | TEC_HUMAN | PSCTK4 |
| Primary ID | P42680 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Inhibitors | 9-(1-Methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone |
| Function | Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ITK | up-regulates 
phosphorylation
|
TEC | 0.381 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TEC | up-regulates
phosphorylation
|
TEC | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BTK | up-regulates
phosphorylation
|
TEC | 0.473 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TEC | up-regulates activity
phosphorylation
|
BMX | 0.337 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TEC | down-regulates activity 
phosphorylation
|
BTK | 0.473 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TEC | up-regulates
phosphorylation
|
BMX | 0.337 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TEC | up-regulates activity
phosphorylation
|
STAP1 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STAP1 | up-regulates activity
binding
|
TEC | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 9-(1-Methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone | down-regulates activity
chemical inhibition
|
TEC | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |