Summary

Name ACAA2
Full Name 3-ketoacyl-CoA thiolase, mitochondrial
Synonyms Acetyl-CoA acyltransferase, Beta-ketothiolase, Mitochondrial 3-oxoacyl-CoA thiolase, T1 |
Primary ID P42765
Links - -
Type protein
Relations 4
Pathways Fatty Acid Beta-Oxidation
Function In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312).

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Relations

Regulator Mechanism target score ℹ
+ ACAA2down-regulates quantity img/direct_inhibition.png chemical modification acetyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACAA2down-regulates quantity img/direct_inhibition.png chemical modification acyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACAA2up-regulates quantity img/direct-activation.png chemical modification 3-oxo-fatty acyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ ACAA2up-regulates quantity img/direct-activation.png chemical modification coenzyme A(4-) 0.8
Publications: 1 Organism: Homo Sapiens