Summary

Name SLC1A3
Full Name Excitatory amino acid transporter 1
Synonyms Sodium-dependent glutamate/aspartate transporter 1, GLAST-1, Solute carrier family 1 member 3 | EAAT1, GLAST, GLAST1
Primary ID P43003
Links - -
Type protein
Relations 4
Inhibitors 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-YL)-5-oxo-4H-chromene-3-carbonitrile
Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SLC1A3 0.427
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding SLC1A3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC1A3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization glutamic acid 0.8
Publications: 1 Organism: Homo Sapiens