3.0
Summary
| Name |  SLC1A3View Modifications |
| Full Name | Excitatory amino acid transporter 1 |
| Synonyms | Sodium-dependent glutamate/aspartate transporter 1, GLAST-1, Solute carrier family 1 member 3 | EAAT1, GLAST, GLAST1 |
| Primary ID | P43003 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Inhibitors | 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-YL)-5-oxo-4H-chromene-3-carbonitrile |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SGK1 | up-regulates activity 
phosphorylation
|
SLC1A3 | 0.425 |
| Publications: | 1 | Organism: | In Vitro | |
| + | 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-YL)-5-oxo-4H-chromene-3-carbonitrile | down-regulates activity 
chemical inhibition
|
SLC1A3 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SLC1A3 | up-regulates quantity
relocalization
|
glutamic acid | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CAV1 | down-regulates activity
binding
|
SLC1A3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |