| + |
ZNRF1 | down-regulates quantity by destabilization 
polyubiquitination
|
CAV1 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272327 |
Lys39 |
MADELSEkQVYDAHT |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 28593998 |
The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation. ZNRF1 mediates CAV1 polyubiquitination at lysine 39 and promote CAV1 degradation to modulate TLR4-mediated immune response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A2 |
phosphorylation
|
CAV1 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250981 |
Ser88 |
FDGIWKAsFTTFTVT |
in vitro |
|
| pmid |
sentence |
| 8058322 |
Here, we have identified this serine kinase activity as a casein kinase II-like enzyme, since the phosphorylation of caveolin-rich membrane domains is stimulated and inhibited by known effectors of casein kinase II (poly-L-lysine, endogenous polyamines, and a casein kinase II inhibitor peptide), but is unaffected by modulators of other known kinases. In support of these observations, caveolin contains a consensus sequence for casein kinase II phosphorylation in its cytoplasmic N-terminal domain (Ser-88) |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CSNK2A1 |
phosphorylation
|
CAV1 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250835 |
Ser88 |
FDGIWKAsFTTFTVT |
in vitro |
|
| pmid |
sentence |
| 8058322 |
Here, we have identified this serine kinase activity as a casein kinase II-like enzyme, since the phosphorylation of caveolin-rich membrane domains is stimulated and inhibited by known effectors of casein kinase II (poly-L-lysine, endogenous polyamines, and a casein kinase II inhibitor peptide), but is unaffected by modulators of other known kinases. In support of these observations, caveolin contains a consensus sequence for casein kinase II phosphorylation in its cytoplasmic N-terminal domain (Ser-88) |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PTPN1 |
dephosphorylation
|
CAV1 |
0.554 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248430 |
Tyr14 |
VDSEGHLyTVPIREQ |
in vitro |
|
| pmid |
sentence |
| 16388599 |
The scaffolding protein caveolin-1 is also a participant in these pathways and is specifically phosphorylated on tyrosine 14, when these pathways are activated. Here, we provide evidence that PTP1B can efficiently catalyze the removal of the phosphoryl group from phosphocaveolin-1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SRC | down-regulates activity
phosphorylation
|
CAV1 |
0.756 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118007 |
Tyr14 |
VDSEGHLyTVPIREQ |
Homo sapiens |
|
| pmid |
sentence |
| 12921535 |
Caveolin-1 is phosphorylated on tyr(14) in response to both oxidative and hyperosmotic stress. In the present paper, we show that this phosphorylation requires activation of the src family kinase fyn |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FYN | down-regulates activity
phosphorylation
|
CAV1 |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118003 |
Tyr14 |
VDSEGHLyTVPIREQ |
Homo sapiens |
|
| pmid |
sentence |
| 12921535 |
Caveolin-1 is phosphorylated on tyr(14) in response to both oxidative and hyperosmotic stress. In the present paper, we show that this phosphorylation requires activation of the src family kinase fyn.Therefore, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAV1 | up-regulates 
binding
|
LRP6 |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16890161 |
Overall, our data suggest that wnt-3a triggers the interaction of lrp6 with caveolin and promotes recruitment of axin to lrp6 phosphorylated by glycogen synthase kinase-3beta and that caveolin thereby inhibits the binding of beta-catenin to axin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAV1 | up-regulates quantity 
relocalization
|
ANXA3 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262215 |
|
|
Homo sapiens |
Hepatoma Cell |
| pmid |
sentence |
| 26095609 |
There has been no study regarding the route of entry of exogenous ANXA3 in any cell type thus far. We found exogenous ANXA3 to be internalized into HCC cells through caveolin-1-mediated, but not HSPG-mediated, endocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN14 | down-regulates activity
dephosphorylation
|
CAV1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277054 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32152405 |
Finally, PTPN14 overexpression in B16F10 cells reduced the ability of CAV1 to induce metastasis in vivo.|Moreover, the CAV1 (Y14F) mutant protein was shown to co-immunoprecipitate with PTPN14 even in the absence of E-cadherin, and overexpression of PTPN14 reduced CAV1 phosphorylation on tyrosine 14, as well as suppressed CAV1 enhanced cell migration, invasion and Rac-1 activation in B16F10, metastatic colon [HT29 (US)] and breast cancer (MDA-MB-231) cell lines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAV1 | down-regulates activity
binding
|
SLC1A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264807 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26690923 |
EAAT3 has previously been shown to form complexes with caveolin-1, a major component of caveolae, which participate in the regulation of transport proteins. The present study explored the impact of caveolin-1 on electrogenic transport by excitatory amino acid transporter isoforms EAAT1-4. caveolin-1 is a powerful negative regulator of the excitatory glutamate transporters EAAT1, EAAT2, EAAT3, and EAAT4. Caveolin-1 has been shown to form complexes with the excitatory amino acid transporter EAAT3 (EAAC1) (Gonzalez et al. 2007) and may thus modify the EAAT isoforms by direct interaction with the carriers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAV1 | down-regulates activity
binding
|
SLC1A3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264808 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26690923 |
EAAT3 has previously been shown to form complexes with caveolin-1, a major component of caveolae, which participate in the regulation of transport proteins. The present study explored the impact of caveolin-1 on electrogenic transport by excitatory amino acid transporter isoforms EAAT1-4. caveolin-1 is a powerful negative regulator of the excitatory glutamate transporters EAAT1, EAAT2, EAAT3, and EAAT4. Caveolin-1 has been shown to form complexes with the excitatory amino acid transporter EAAT3 (EAAC1) (Gonzalez et al. 2007) and may thus modify the EAAT isoforms by direct interaction with the carriers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAV1 | down-regulates activity
binding
|
SLC1A6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264810 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26690923 |
EAAT3 has previously been shown to form complexes with caveolin-1, a major component of caveolae, which participate in the regulation of transport proteins. The present study explored the impact of caveolin-1 on electrogenic transport by excitatory amino acid transporter isoforms EAAT1-4. caveolin-1 is a powerful negative regulator of the excitatory glutamate transporters EAAT1, EAAT2, EAAT3, and EAAT4. Caveolin-1 has been shown to form complexes with the excitatory amino acid transporter EAAT3 (EAAC1) (Gonzalez et al. 2007) and may thus modify the EAAT isoforms by direct interaction with the carriers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAV1 | up-regulates quantity
relocalization
|
Fatty acid |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28457600 |
Astrocytes and endothelial cells, two major components of the blood brain barrier, are the major contributors to the transportation of PUFAs from the circulation to brain. There are four classes of lipid transportation proteins involved in lipid synthesis and transportation in adult brain, including fatty acid translocase (FAT/CD36), caveolin-1, fatty acid binding proteins (FABPs) long chain acyl-coA synthase (ACS) and fatty acid transportation proteins (FATPs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAV1 | down-regulates activity
binding
|
SLC1A2 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264809 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26690923 |
EAAT3 has previously been shown to form complexes with caveolin-1, a major component of caveolae, which participate in the regulation of transport proteins. The present study explored the impact of caveolin-1 on electrogenic transport by excitatory amino acid transporter isoforms EAAT1-4. caveolin-1 is a powerful negative regulator of the excitatory glutamate transporters EAAT1, EAAT2, EAAT3, and EAAT4. Caveolin-1 has been shown to form complexes with the excitatory amino acid transporter EAAT3 (EAAC1) (Gonzalez et al. 2007) and may thus modify the EAAT isoforms by direct interaction with the carriers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates
binding
|
CAV1 |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251683 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23339905 |
He mGR appears to reside in caveolae and its association with caveolin-1 (Cav-1) was clearly detected in two of the four cell lines investigated using double recognition proximity ligation assay. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
CAV1 | up-regulates activity
relocalization
|
HMGA1 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254428 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22706202 |
CAV1 was shown to stimulate GLUT3 transcription via an HMGA1-binding site within the GLUT3 promoter. HMGA1 was found to interact with and activate the GLUT3 promoter and CAV1 increased the HMGA1 activity by enhancing its nuclear localization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CAV1
- 
- 