Summary

Name MAGEA3
Full Name Melanoma-associated antigen 3
Synonyms Antigen MZ2-D, Cancer/testis antigen 1.3, CT1.3, MAGE-3 antigen | MAGE3
Primary ID P43357
Links - -
Type protein
Relations 3
Function Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy (PubMed:20864041, PubMed:31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041). May play a role in embryonal development and tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041). In vitro promotes cell viability in melanoma cell lines (PubMed:17942928). Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes (PubMed:8113684).

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Relations

Regulator Mechanism target score ℹ
+ MAGEA3up-regulates activity img/direct-activation.png binding TRIM28 0.449
Publications: 1 Organism: Homo Sapiens
+ Cullin4-RBX1-DDB1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination MAGEA3 0.2
Publications: 1 Organism: Homo Sapiens
+ DCAF12down-regulates quantity by destabilization img/direct_inhibition.png binding MAGEA3 0.2
Publications: 1 Organism: Homo Sapiens