4.0
Summary
| Name |  TRIM28View Modifications |
| Full Name | Transcription intermediary factor 1-beta |
| Synonyms | TIF1-beta, E3 SUMO-protein ligase TRIM28, 6.3.2.-, KRAB-associated protein 1, KAP-1, KRAB-interacting protein 1, KRIP-1, Nuclear corepressor KAP-1, RING finger protein 96, Tripartite motif-containing protein 28 | KAP1, RNF96, TIF1B |
| Primary ID | Q13263 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Function | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CHEK2 | down-regulates activity 
phosphorylation
|
TRIM28 | 0.412 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCD | down-regulates
phosphorylation
|
TRIM28 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RIPK3 | down-regulates activity
phosphorylation
|
TRIM28 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPP1CA | up-regulates activity 
dephosphorylation
|
TRIM28 | 0.323 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM28 | down-regulates quantity by repression 
transcriptional regulation
|
ALDOA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM28 | up-regulates activity
binding
|
MDM2 | 0.597 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCAD1 | up-regulates activity
binding
|
TRIM28 | 0.504 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPP4C | down-regulates activity
dephosphorylation
|
TRIM28 | 0.359 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAGEC2 | up-regulates activity
binding
|
TRIM28 | 0.506 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM28 | down-regulates quantity by destabilization
ubiquitination
|
FBP1 | 0.311 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAGEA3 | up-regulates activity
binding
|
TRIM28 | 0.436 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM28 | down-regulates quantity by repression
transcriptional regulation
|
Aldolase | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |