Relation Results

Summary

Name TRIM28
Full Name Transcription intermediary factor 1-beta
Synonyms TIF1-beta, E3 SUMO-protein ligase TRIM28, 6.3.2.-, KRAB-associated protein 1, KAP-1, KRAB-interacting protein 1, KRIP-1, Nuclear corepressor KAP-1, RING finger protein 96, Tripartite motif-containing protein 28 | KAP1, RNF96, TIF1B
Primary ID Q13263
Links - -
Type protein
Relations 10
Function Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleoso ...
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Type: Score: Layout: SPV 
0.20.3250.20.5130.4420.5150.20.3620.3120.588PRKCDTRIM28PPP1CAAldolaseSMARCAD1MAGEA3MAGEC2ALDOAPPP4CFBP1MDM2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCDdown-regulates img/direct_inhibition.png phosphorylation TRIM28 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-179250 Ser473 SGVKRSRsGEGEVSG Homo sapiens
pmid sentence
This work demonstrates that tif1beta is phosphorylated on ser473, the alteration of which is dynamically associated with cell cycle progression and functionally linked to transcriptional regulation. Phosphorylation of tif1beta/ser473 is mediated by the pkcdelta pathway and is closely linked to cell proliferation. Phosphorylation of tif1beta/ser473 coincides with the induction of cell cycle gene cyclin a2 at the s-phase. Promoter of cyclin a2 gene is occupied by tif1beta and such occupancy is inversely correlated with ser473 phosphorylation. Non-phosphorylated tif1beta/ser473 allowed greater tif1beta association with the regulatory regions and the consequent repression of these genes.
Publications: 1 Organism: Homo Sapiens
+ PPP1CAup-regulates activity img/direct-activation.png dephosphorylation TRIM28 0.325
Identifier Residue Sequence Organism Cell Line
SIGNOR-277075 Ser824 LPGAGLSsQELSGGP Homo sapiens
pmid sentence
PP1\u03b1 dephosphorylates KAP1 at Ser 824 .
Publications: 1 Organism: Homo Sapiens
+ TRIM28down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation Aldolase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270228 Homo sapiens
pmid sentence
We previously reported that ZNF224, a novel Krüppel-associated box-containing zinc-finger protein, represses aldolase A gene transcription by interacting with the KAP-1 co-repressor.
Publications: 1 Organism: Homo Sapiens
+ SMARCAD1up-regulates activity img/direct-activation.png binding TRIM28 0.513
Identifier Residue Sequence Organism Cell Line
SIGNOR-239838 Homo sapiens
pmid sentence
SMARCAD1 interacts with HDAC1 and KAP1 and is required for their binding to heterochromatin
Publications: 1 Organism: Homo Sapiens
+ MAGEA3up-regulates activity img/direct-activation.png binding TRIM28 0.442
Identifier Residue Sequence Organism Cell Line
SIGNOR-267592 Homo sapiens Liver Cancer Cell
pmid sentence
In this study, we demonstrated that the tripartite motif-containing protein 28 (TRIM28) binds directly to and promotes FBP1 for ubiquitination and degradation. MAGE-A3 and MAGE-C2, which are known to be overexpressed in HCC, can enhance TRIM28-dependent degradation of FBP1 by forming ubiquitin ligase complexes with TRIM28.
Publications: 1 Organism: Homo Sapiens
+ MAGEC2up-regulates activity img/direct-activation.png binding TRIM28 0.515
Identifier Residue Sequence Organism Cell Line
SIGNOR-267593 Homo sapiens Liver Cancer Cell
pmid sentence
In this study, we demonstrated that the tripartite motif-containing protein 28 (TRIM28) binds directly to and promotes FBP1 for ubiquitination and degradation. MAGE-A3 and MAGE-C2, which are known to be overexpressed in HCC, can enhance TRIM28-dependent degradation of FBP1 by forming ubiquitin ligase complexes with TRIM28.
Publications: 1 Organism: Homo Sapiens
+ TRIM28down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ALDOA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255628 Homo sapiens
pmid sentence
We previously reported that ZNF224, a novel Krüppel-associated box-containing zinc-finger protein, represses aldolase A gene transcription by interacting with the KAP-1 co-repressor.
Publications: 1 Organism: Homo Sapiens
+ PPP4Cdown-regulates activity img/direct_inhibition.png dephosphorylation TRIM28 0.362
Identifier Residue Sequence Organism Cell Line
SIGNOR-277163 Homo sapiens
pmid sentence
PP4 dephosphorylated pKAP1 in vitro.
Publications: 1 Organism: Homo Sapiens
+ TRIM28down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination FBP1 0.312
Identifier Residue Sequence Organism Cell Line
SIGNOR-267591 Homo sapiens Liver Cancer Cell
pmid sentence
In this study, we demonstrated that the tripartite motif-containing protein 28 (TRIM28) binds directly to and promotes FBP1 for ubiquitination and degradation. MAGE-A3 and MAGE-C2, which are known to be overexpressed in HCC, can enhance TRIM28-dependent degradation of FBP1 by forming ubiquitin ligase complexes with TRIM28.
Publications: 1 Organism: Homo Sapiens
+ TRIM28up-regulates activity img/direct-activation.png binding MDM2 0.588
Identifier Residue Sequence Organism Cell Line
SIGNOR-240405 Homo sapiens HEK-293 Cell
pmid sentence
we present evidence that MDM2 interacts with the nuclear corepressor KAP1. MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.
Publications: 1 Organism: Homo Sapiens
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