| + |
CLOCK/BMAL1 | up-regulates quantity by expression 
transcriptional regulation
|
NAMPT |
0.597 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268021 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19299583 |
Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice. Inhibition of NAMPT promotes oscillation of the clock gene Per2 by releasing CLOCK:BMAL1 from suppression by SIRT1. In turn, the circadian transcription factor CLOCK binds to and up-regulates Nampt, thus completing a feedback loop involving NAMPT/NAD+ and SIRT1/CLOCK:BMAL1. Transduction of Clock/Bmal1 into mouse embryonic fibroblasts appeared to up-regulate Nampt expression ∼1.6-fold (Fig. 3E). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock |
| + |
AMPK | up-regulates quantity 
|
NAMPT |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238824 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18477450 |
Activated AMPK was required to promote GR-induced transcription of the NAD+ biosynthetic enzyme Nampt |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock |
| + |
NAMPT | down-regulates 
|
CLOCK/BMAL1 |
0.597 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253721 |
|
|
|
|
| pmid |
sentence |
| 19299583 |
Using Per2:luciferase transcriptional reporter assays in HEK293 cells (Fig. 2C-E; S2), we show that inhibition of NAMPT by FK866 led to a significant increase in the CLOCK:BMAL1-driven transcription of the Per2:luciferase reporter (Fig. 2C), indicating that reduced NAMPT-mediated NAD+ biosynthesis released CLOCK:BMAL1 from the SIRT1-dependent suppression. |
|
| Publications: |
1 |
| Pathways: | Circadian clock |
| + |
PRKAA1 | up-regulates quantity
transcriptional regulation
|
NAMPT |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238598 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18477450 |
Activated AMPK was required to promote GR-induced transcription of the NAD+ biosynthetic enzyme Nampt |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NAMPT | up-regulates quantity
chemical modification
|
NAD(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238602 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12555668 |
Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesi |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
3.0
NAMPT
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