Summary

Name NAMPT
Full Name Nicotinamide phosphoribosyltransferase
Synonyms NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin | PBEF, PBEF1
Primary ID P43490
Links - -
Type protein
Relations 5
Pathways Circadian clock
Function Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png chemical modification NAD(1-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NAMPT 0.598
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity img/indirect-activation.png transcriptional regulation NAMPT 0.306
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png CLOCK/BMAL1 0.598
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity img/indirect-activation.png transcriptional regulation NAMPT 0.278
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock