Summary

Name USP5
Full Name Ubiquitin carboxyl-terminal hydrolase 5
Synonyms Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5 | ISOT
Primary ID P45974
Links - -
Type protein
Relations 3
Pathways Ubiquitin activation
Function Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

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Relations

Regulator Mechanism target score ℹ
+ USP5up-regulates quantity img/direct-activation.png cleavage UBC 0.837
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ USP5up-regulates quantity img/direct-activation.png cleavage Ubiquitin 0.837
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ USP5up-regulates quantity img/direct-activation.png cleavage UBB 0.751
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation