+ |
CDK1 | up-regulates
phosphorylation
|
FOXM1 |
0.751 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-187876 |
Ser251 |
MIQFAINsTERKRMT |
Homo sapiens |
|
pmid |
sentence |
19737929 |
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1the phosphorylation at ser-251 is critical for the activation of foxm1. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-187880 |
Thr611 |
ETLPISStPSKSVLP |
Homo sapiens |
|
pmid |
sentence |
19737929 |
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1further analysis reveals that the leu-641 residue within an lxl motif is required for the recruitment of the cyclin-cdk complex, and the thr-596 residue is a critical cdk1 phosphorylation site within the activation domain of foxm1b. Cdk-dependent phosphorylation stimulates the foxm1b transcriptional activity |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
CyclinB/CDK1 | up-regulates
phosphorylation
|
FOXM1 |
0.753 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-216833 |
Ser251 |
MIQFAINsTERKRMT |
Homo sapiens |
|
pmid |
sentence |
19737929 |
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1the phosphorylation at ser-251 is critical for the activation of foxm1. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-216837 |
Thr611 |
ETLPISStPSKSVLP |
Homo sapiens |
|
pmid |
sentence |
19737929 |
A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1further analysis reveals that the leu-641 residue within an lxl motif is required for the recruitment of the cyclin-cdk complex, and the thr-596 residue is a critical cdk1 phosphorylation site within the activation domain of foxm1b. Cdk-dependent phosphorylation stimulates the foxm1b transcriptional activity |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
CHEK2 | up-regulates
phosphorylation
|
FOXM1 |
0.709 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-150746 |
Ser376 |
PLLPRVSsYLVPIQF |
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
17101782 |
Chk2 mediates stabilization of the foxm1 transcription factor to stimulate expression of dna repair genesthis phosphorylation of foxm1 on serine residue 361 caused increased stability of the foxm1 protein |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDK4 | up-regulates
phosphorylation
|
FOXM1 |
0.607 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-177251 |
Ser4 |
sPRRPLIL |
Homo sapiens |
|
pmid |
sentence |
22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627) |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-177255 |
Thr611 |
ETLPISStPSKSVLP |
Homo sapiens |
|
pmid |
sentence |
22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627) |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-177259 |
Thr620 |
SKSVLPRtPESWRLT |
Homo sapiens |
|
pmid |
sentence |
22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627) |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-177263 |
Thr627 |
TPESWRLtPPAKVGG |
Homo sapiens |
|
pmid |
sentence |
22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1these data identify five overlapping in vivo and in vitro cdk4/6 target sites in foxm1 (s4, s35, t611, t620 and t627) |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-177266 |
|
|
Homo sapiens |
|
pmid |
sentence |
22094256 |
We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1, thereby maintain expression of g1/s phase genes, suppress the levels of reactive oxygen species (ros), and protect cancer cells from senescence. |
|
Publications: |
5 |
Organism: |
Homo Sapiens |
+ |
PLK1 | up-regulates
phosphorylation
|
FOXM1 |
0.694 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-187888 |
Ser730 |
VLDTMNDsLSKILLD |
Homo sapiens |
|
pmid |
sentence |
19737929 |
It has been reported that plk1 could directly phosphorylate foxm1 at ser-715 and ser-724 for full activation and proper mitotic progression |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-187892 |
Ser739 |
SKILLDIsFPGLDED |
Homo sapiens |
|
pmid |
sentence |
19737929 |
It has been reported that plk1 could directly phosphorylate foxm1 at ser-715 and ser-724 for full activation and proper mitotic progression |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
CDK2 | up-regulates activity
phosphorylation
|
FOXM1 |
0.739 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250731 |
Thr611 |
ETLPISStPSKSVLP |
|
U2-OS Cell |
pmid |
sentence |
15024056 |
We demonstrated that FoxM1B transcriptional activity requires binding of either S-phase or M-phase Cdk-cyclin complexes to mediate efficient Cdk phosphorylation of the FoxM1B Thr 596 residue, which is essential for recruitment of p300/CBP coactivator proteins. |
|
Publications: |
1 |
+ |
TEAD1 | up-regulates quantity by expression
transcriptional regulation
|
FOXM1 |
0.277 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-194371 |
|
|
Homo sapiens |
|
pmid |
sentence |
22286761 |
Yap directly induced the transcription of ccnd1 and foxm1, in cooperation with tead transcription factor. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FOXM1 | up-regulates quantity by expression
|
SLC27A2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260414 |
|
|
Homo sapiens |
|
pmid |
sentence |
31949772 |
FOXM1 as a prognostic biomarker promotes endometrial cancer progression via transactivation of SLC27A2 expression. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |