4.0
Summary
| Name |  GLRBView Modifications |
| Full Name | Glycine receptor subunit beta |
| Synonyms | Glycine receptor 58 kDa subunit |
| Primary ID | P48167 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRC | up-regulates 
phosphorylation
|
GLRB | 0.271 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain, Kidney | |||
| + | glycine | up-regulates activity
chemical activation
|
GLRB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Retina, Spinal Cord, Brain Stem | |||