3.0
Summary
| Name |  IREB2View Modifications |
| Full Name | Iron-responsive element-binding protein 2 |
| Synonyms | IRE-BP 2, Iron regulatory protein 2, IRP2 |
| Primary ID | P48200 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 | down-regulates 
phosphorylation
|
IREB2 | 0.366 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CyclinB/CDK1 | down-regulates
phosphorylation
|
IREB2 | 0.366 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDC14A | up-regulates activity 
dephosphorylation
|
IREB2 | 0.361 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | down-regulates quantity by destabilization
ubiquitination
|
IREB2 | 0.366 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXL5 | down-regulates quantity by destabilization
binding
|
IREB2 | 0.738 |
| Publications: | 1 | Organism: | Homo Sapiens | |