| + |
CHEK2 | up-regulates 
phosphorylation
|
VHL |
0.466 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177091 |
Ser111 |
GTGRRIHsYRGHLWL |
Homo sapiens |
Kidney Cancer Cell |
| pmid |
sentence |
| 22071692 |
We demonstrated that checkpoint kinase-2 (chk2) binds to the beta-domain of pvhl and phosphorylates ser 111 on dna damage. Notably, this modification enhances pvhl-mediated transactivation of p53 by recruiting p300 and tip60 to the chromatin of p53 target gene |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEK1 | down-regulates quantity by destabilization 
phosphorylation
|
VHL |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276434 |
Ser168 |
RCLQVVRsLVKPENY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23255108 |
Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization. Mutation of pVHL at S-168 increases protein stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates quantity by destabilization
phosphorylation
|
VHL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277836 |
Ser80 |
QVIFCNRsPRVVLPV |
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 36813923 |
Mechanistically, CDK1 directly phosphorylates pVHL at Ser80, which primes the recognition of pVHL by PIN1. PIN1 then binds to phosphorylated pVHL and facilitates the recruitment of the E3 ligase WSB1, therefore targeting pVHL for ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VHL | down-regulates activity
binding
|
CARD9 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266899 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17936701 |
We found that pVHL associates with the NF-kappaB agonist Card9 but does not target Card9 for destruction. Instead, pVHL serves as an adaptor that promotes the phosphorylation of the Card9 C terminus by CK2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257603 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17936701 |
We found that pVHL associates with the NF-kappaB agonist Card9 but does not target Card9 for destruction. Instead, pVHL serves as an adaptor that promotes the phosphorylation of the Card9 C terminus by CK2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
VHL | form complex 
binding
|
VCB-Cul2 |
0.818 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11574546 |
The von Hippel-Lindau tumor-suppressor protein (pVHL) forms a protein complex (VCB-Cul2) with elongin C, elongin B, Cul-2, and Rbx1, which functions as a ubiquitin-protein ligase (E3). The alpha-subunits of the hypoxia-inducible factors have been identified as targets for the VCB-Cul2 ubiquitin ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VHL | up-regulates quantity by stabilization
binding
|
TP53 |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256594 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16678111 |
Here we found that pVHL directly associates with and stabilizes p53 by suppressing Mdm2-mediated ubiquitination and nuclear export of p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VHL | up-regulates quantity by expression 
transcriptional regulation
|
DAB2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255602 |
|
|
Homo sapiens |
Renal Cell Carcinoma Cell |
| pmid |
sentence |
| 15824735 |
three of the nine targets had been identified previously as candidate TSGs (DOC-2/DAB2, CDKN1C and SPARC) and all were upregulated by wild-type pVHL. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VHL | down-regulates quantity by destabilization
ubiquitination
|
IREB2 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271421 |
|
|
Homo sapiens |
RCC 786-O Cell |
| pmid |
sentence |
| 15777842 |
We show here that IRP2 can interact with pVHL in co-transfection/co-immunoprecipitation assays. Furthermore, pVHL is able to promote the ubiquitination and the decay of transfected IRP2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VHL | up-regulates quantity by expression
transcriptional regulation
|
SPARC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255603 |
|
|
Homo sapiens |
Renal Cell Carcinoma Cell |
| pmid |
sentence |
| 15824735 |
three of the nine targets had been identified previously as candidate TSGs (DOC-2/DAB2, CDKN1C and SPARC) and all were upregulated by wild-type pVHL. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VHL | down-regulates quantity by repression 
transcriptional regulation
|
KLF10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253213 |
|
|
Homo sapiens |
RCC 786-O Cell |
| pmid |
sentence |
| 18359287 |
In this study, we show that both TGFBI and KLF10 are down-regulated by VHL in 786-0 cells, and that KLF10 may serve as a transactivator of the TGFBI promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VHL | down-regulates
ubiquitination
|
HIF-1 complex |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80969 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10944113 |
Here we show that the product of the von hippel-lindau (vhl) tumor suppressor gene mediated ubiquitylation and proteasomal degradation of hif-1 alpha under normoxic conditions via interaction with the core of the oxygen-dependent degradation domain of hif-1 alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VHL | up-regulates quantity by expression
transcriptional regulation
|
CDKN1C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255601 |
|
|
Homo sapiens |
Renal Cell Carcinoma Cell |
| pmid |
sentence |
| 15824735 |
three of the nine targets had been identified previously as candidate TSGs (DOC-2/DAB2, CDKN1C and SPARC) and all were upregulated by wild-type pVHL. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
VHL
- 
- 