4.0
Summary
| Name |  RFX2
|
| Full Name | DNA-binding protein RFX2 |
| Synonyms | Regulatory factor X 2 | |
| Primary ID | P48378 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene H1-6 (By similarity). |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RFX2 | up-regulates 
|
Cilium_assembly | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |