| + |
RAB8A | up-regulates 
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252148 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18694559 |
CEP290 cooperates with Rab8a to promote ciliogenesis and this function is antagonized by CP110 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNTRL | down-regulates 
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252150 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18694559 |
CEP290 cooperates with Rab8a to promote ciliogenesis and this function is antagonized by CP110. CP110 in this complex is to keep CEP290 inactive in growing cells until cells are ready to undergo ciliogenesis as they transit into the quiescent state |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cytoplasmic_Dynein | up-regulates
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265022 |
|
|
|
|
| pmid |
sentence |
| 16440056 |
A second cytoplasmic dynein complex, cytoplasmic dynein 2, has a role in intraflagellar transport (IFT), a process required for ciliary/flagellar assembly |
|
| Publications: |
1 |
| + |
CPLANE1 | up-regulates
|
Cilium_assembly |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35740972 |
Some gene complexes, such as BBSome or CPLANE (ciliogenesis and planar polarity effector), have been linked to ciliogenesis. CPLANE complex is composed of INTU, FUZ and WDPCP, which bind to JBTS17 and RSG1 for cilia formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CPLANE2 | up-regulates
|
Cilium_assembly |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35740972 |
Some gene complexes, such as BBSome or CPLANE (ciliogenesis and planar polarity effector), have been linked to ciliogenesis. CPLANE complex is composed of INTU, FUZ and WDPCP, which bind to JBTS17 and RSG1 for cilia formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ITF complex | up-regulates
|
Cilium_assembly |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280961 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22118932 |
The process of Intraflagellar Transport (IFT) is of central importance for both the assembly and maintenance of cilia, as it delivers building blocks from their site of synthesis in the cell body to the ciliary assembly site at the tip of the cilium. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RFX3 | up-regulates
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266927 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32725242 |
RFX2 and RFX3 are key regulators of ependymal cell ciliogenesis in vitro and in vivo. We show here that RFX2 and RFX3 have both redundant and specific functions in the biogenesis of motile cilia on mouse ependymal cells, whereas RFX1 does not seem to play a key regulatory role in this process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEP290 | up-regulates
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18694559 |
CEP290 cooperates with Rab8a to promote ciliogenesis and this function is antagonized by CP110 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RFX2 | up-regulates
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266928 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32725242 |
RFX2 and RFX3 are key regulators of ependymal cell ciliogenesis in vitro and in vivo. We show here that RFX2 and RFX3 have both redundant and specific functions in the biogenesis of motile cilia on mouse ependymal cells, whereas RFX1 does not seem to play a key regulatory role in this process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
AHI1 | up-regulates
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269080 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 23532844 |
Mutations in AHI1 cause Joubert syndrome (JBTS), a neurodevelopmental ciliopathy, characterized by midbrain-hindbrain malformations and motor/cognitive deficits. Here, we show that primary cilia (PC) formation is decreased in fibroblasts from individuals with JBTS and AHI1 mutations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIF14 | up-regulates
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266421 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32348467 |
We show that RNAi depletion of KIF14 specifically leads to defects in ciliogenesis and basal body (BB) biogenesis, as its absence hampers the efficiency of primary cilium formation and the dynamics of primary cilium elongation, and disrupts the localization of the distal appendage proteins SCLT1 and FBF1 and components of the IFT-B complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Cilium_assembly