| + |
NFE2L2 | up-regulates quantity by expression 
transcriptional regulation
|
GCLC |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279868 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39534872 |
NFE2L2 is stabilized and translocates to the nucleus, where it dimerizes with sMAF proteins. This complex binds to AREs to mediate the transcription of genes involved in iron metabolism, GSH metabolism, and ROS detoxification.Importantly, GCLC, GCLM, GSS, and GSR are transcriptional targets of NFE2L2. Their upregulation is implicated in conferring resistance to ferroptosis across various contexts, including chemotherapy and radiation therapy |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256277 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24024136 |
In both models, the inducer-modified and Nrf2-bound Keap1 is inactivated and, consequently, newly synthesized Nrf2 proteins bypass Keap1 and translocate into the nucleus, bind to the ARE and drive the expression of Nrf2 target genes such as NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HMOX1), glutamate-cysteine ligase (GCL) and glutathione S transferases (GSTs). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NFE2L2 | down-regulates quantity by repression 
transcriptional regulation
|
GCLC |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254643 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22459801 |
Different expression pattern of Nrf2 regulated genes in end-stage liver disease samples were observed: glutamate-cysteine ligase (GCLC) and glutathione-S-transferase A1 (GSTA1) were significantly down-regulated in most liver disease groups, whereas heme oxidase 1 (HMOX1) and NAD(P)H dehydrogenase [quinone] 1 (NQO1) were not significantly suppressed. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTF1 | up-regulates quantity by expression 
transcriptional regulation
|
GCLC |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254599 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15378601 |
MRE-binding transcription factor-1 (MTF-1) is a highly conserved heavy metal-induced transcriptional activator. MTF-1 also activates transcription in response to oxidative stress and regulates the expression of several cytoprotective factor genes, including MT, gamma-glutamylcysteine synthetase, and Cu/Zn-superoxide dismutase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GCLC
- 
- 