+ |
LATS1 | down-regulates activity
phosphorylation
|
MTF1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275473 |
Ser152 |
EGCPRTYsTAGNLRT |
|
|
pmid |
sentence |
35027733 |
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1|the Hippo pathway kinase LATS phosphorylates and inhibits MTF1|LATS phosphorylates MTF1 at S152 and disrupts its association with the promoters of heavy metal response genes, resulting in the loss of heavy metal response gene expression |
|
Publications: |
1 |
+ |
LATS2 | down-regulates activity
phosphorylation
|
MTF1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275475 |
Ser152 |
EGCPRTYsTAGNLRT |
|
|
pmid |
sentence |
35027733 |
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1|the Hippo pathway kinase LATS phosphorylates and inhibits MTF1|LATS phosphorylates MTF1 at S152 and disrupts its association with the promoters of heavy metal response genes, resulting in the loss of heavy metal response gene expression |
|
Publications: |
1 |
+ |
MTF1 | up-regulates quantity by expression
transcriptional regulation
|
SOD1 |
0.291 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254601 |
|
|
Homo sapiens |
|
pmid |
sentence |
15378601 |
MRE-binding transcription factor-1 (MTF-1) is a highly conserved heavy metal-induced transcriptional activator. MTF-1 also activates transcription in response to oxidative stress and regulates the expression of several cytoprotective factor genes, including MT, gamma-glutamylcysteine synthetase, and Cu/Zn-superoxide dismutase. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTF1 | up-regulates quantity by expression
transcriptional regulation
|
MCAT |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254600 |
|
|
Homo sapiens |
|
pmid |
sentence |
15378601 |
MRE-binding transcription factor-1 (MTF-1) is a highly conserved heavy metal-induced transcriptional activator. MTF-1 also activates transcription in response to oxidative stress and regulates the expression of several cytoprotective factor genes, including MT, gamma-glutamylcysteine synthetase, and Cu/Zn-superoxide dismutase. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTF1 | up-regulates quantity by expression
transcriptional regulation
|
GCLC |
0.29 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254599 |
|
|
Homo sapiens |
|
pmid |
sentence |
15378601 |
MRE-binding transcription factor-1 (MTF-1) is a highly conserved heavy metal-induced transcriptional activator. MTF-1 also activates transcription in response to oxidative stress and regulates the expression of several cytoprotective factor genes, including MT, gamma-glutamylcysteine synthetase, and Cu/Zn-superoxide dismutase. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |