Summary

Name MTF1
Full Name Metal regulatory transcription factor 1
Synonyms MRE-binding transcription factor, Transcription factor MTF-1 |
Primary ID Q14872
Links - -
Type protein
Relations 5
Function Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation MTF1 0.2
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation MTF1 0.2
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOD1 0.291
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MCAT 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCLC 0.29
Publications: 1 Organism: Homo Sapiens