+ |
CAV1 | down-regulates activity
binding
|
SLC1A6 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264810 |
|
|
Homo sapiens |
Neuron |
pmid |
sentence |
26690923 |
EAAT3 has previously been shown to form complexes with caveolin-1, a major component of caveolae, which participate in the regulation of transport proteins. The present study explored the impact of caveolin-1 on electrogenic transport by excitatory amino acid transporter isoforms EAAT1-4. caveolin-1 is a powerful negative regulator of the excitatory glutamate transporters EAAT1, EAAT2, EAAT3, and EAAT4. Caveolin-1 has been shown to form complexes with the excitatory amino acid transporter EAAT3 (EAAC1) (Gonzalez et al. 2007) and may thus modify the EAAT isoforms by direct interaction with the carriers. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RORA | up-regulates quantity by expression
transcriptional regulation
|
SLC1A6 |
0.254 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266850 |
|
|
Mus musculus |
Cerebellar Purkinje Cell |
pmid |
sentence |
19381306 |
RORα regulates the expression of several genes in Purkinje cells. RORα becomes highly expressed in postmitotic Purkinje cells. It regulates their maturation, particularly dendritic differentiation. Dendritogenesis and the expression of several genes, including Shh, Itpr1, Pcp4, Calb1, Pcp2, and Slc1a6, normally expressed in mature Purkinje cells, are inhibited in RORα-deficient mice. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
SLC1A6 | up-regulates quantity
relocalization
|
glutamic acid |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264805 |
|
|
Homo sapiens |
|
pmid |
sentence |
26687113 |
After release from presynaptic nerve terminals, glutamate is quickly removed from the synaptic cleft by a family of five glutamate transporters, the so-called excitatory amino acid transporters (EAAT1-5). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |