Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250670 |
Thr315 |
AENSRLQtPGGGSKT |
Mus musculus |
C2C12 Cell |
pmid |
sentence |
12832492 |
We identify nestin as a novel in vivo target for cdk5 and p35 kinase, a critical signaling determinant in development. Two cdk5-specific phosphorylation sites on nestin, Thr-1495 and Thr-316, were established, the latter of which was used as a marker for cdk5-specific phosphorylation in vivo. | Cdk5 activity is necessary for differentiation and the concomitant nestin reorganization in C2C12 myoblasts. |
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