Relation Results

Summary

Name SLC4A3
Full Name Anion exchange protein 3
Synonyms AE 3, Anion exchanger 3, CAE3/BAE3, Cardiac/brain band 3-like protein, Neuronal band 3-like protein, Solute carrier family 4 member 3 | AE3
Primary ID P48751
Links - -
Type protein
Relations 2
Function Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and ...
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Type: Score: Layout: SPV 
0.3090.8PRKCESLC4A3hydrogencarbonate

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCEup-regulates activity img/direct-activation.png phosphorylation SLC4A3 0.309
Identifier Residue Sequence Organism Cell Line
SIGNOR-249127 Ser67 EKPSRSYsERDFEFH Homo sapiens HEK-293 Cell
pmid sentence
We conclude that following Ang II stimulation of cells, PKCepsilon phosphorylates serine 67 of the AE3 cytoplasmic domain, inducing the Ang II-induced increase in anion transport observed in the hypertrophic myocardium.
Publications: 1 Organism: Homo Sapiens
+ SLC4A3down-regulates quantity img/direct_inhibition.png relocalization hydrogencarbonate 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264917 Homo sapiens Neuron
pmid sentence
Slc4a10 is a Na+-coupled Cl−-HCO3− exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. In neurons, bicarbonate transport is mainly mediated by members of the SLC4A family of proteins. While the Na+-independent anion-exchanger SLC4A3 lowers the intraneuronal bicarbonate concentration, the Na+-dependent anion exchangers SLC4A8 (NDCBE) and SLC4A10 (NCBE) use the sodium gradient to accumulate bicarbonate in exchange of chloride
Publications: 1 Organism: Homo Sapiens
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