| + |
hydrogencarbonate | up-regulates activity 
chemical activation
|
GABA-A (a6-b2-d) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264928 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC4A10 | up-regulates quantity
relocalization
|
hydrogencarbonate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264687 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 23056253 |
The sodium-driven chloride bicarbonate exchanger NCBE (Slc4a10), a member of the SLC4 family of bicarbonate transporters, uses the transmembrane gradient of sodium to drive cellular net uptake of bicarbonate and to extrude chloride, thereby modulating both intracellular pH (pH(i)) and chloride concentration ([Cl(-)](i)) in neurons. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264919 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26136660 |
Slc4a10 is a Na+-coupled Cl−-HCO3− exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. In neurons, bicarbonate transport is mainly mediated by members of the SLC4A family of proteins. While the Na+-independent anion-exchanger SLC4A3 lowers the intraneuronal bicarbonate concentration, the Na+-dependent anion exchangers SLC4A8 (NDCBE) and SLC4A10 (NCBE) use the sodium gradient to accumulate bicarbonate in exchange of chloride |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SLC4A8 | up-regulates quantity
relocalization
|
hydrogencarbonate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264918 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
Slc4a10 is a Na+-coupled Cl−-HCO3− exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. In neurons, bicarbonate transport is mainly mediated by members of the SLC4A family of proteins. While the Na+-independent anion-exchanger SLC4A3 lowers the intraneuronal bicarbonate concentration, the Na+-dependent anion exchangers SLC4A8 (NDCBE) and SLC4A10 (NCBE) use the sodium gradient to accumulate bicarbonate in exchange of chloride |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a1-b1-g2) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264920 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAD | down-regulates quantity 
chemical modification
|
hydrogencarbonate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267419 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28552578 |
CAD is a 243 kDa polypeptide formed by the fusion of four enzymatic domains that initiate the de novo biosynthesis of pyrimidine nucleotides . The first two domains, glutaminase (GLN) and carbamoyl phosphate synthetase (CPS-II), initiate the pathway, catalyzing the formation of carbamoyl phosphate (CP) from bicarbonate, glutamine, and two ATP molecules. Next, the labile CP is partially channeled to the C-terminal aspartate transcarbamoylase (ATC) domain where it reacts with aspartate to form carbamoyl aspartate. Then, carbamoyl aspartate is condensated to dihydroorotate, the cyclic precursor of the pyrimidine ring, by the dihydroorotase (DHO), a Zn metalloenzyme fused between CPS and ATC domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a2-b1-g2) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264921 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a6-b3-d) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264929 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a4-b3-d) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264925 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC4A3 | down-regulates quantity
relocalization
|
hydrogencarbonate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264917 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
Slc4a10 is a Na+-coupled Cl−-HCO3− exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. In neurons, bicarbonate transport is mainly mediated by members of the SLC4A family of proteins. While the Na+-independent anion-exchanger SLC4A3 lowers the intraneuronal bicarbonate concentration, the Na+-dependent anion exchangers SLC4A8 (NDCBE) and SLC4A10 (NCBE) use the sodium gradient to accumulate bicarbonate in exchange of chloride |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a4-b2-d) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264924 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a4-b1-g2) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264923 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a6-b1-g2) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264927 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a3-b1-g2) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264922 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogencarbonate | up-regulates quantity
precursor of
|
carbamoyl phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267417 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28552578 |
CAD is a 243 kDa polypeptide formed by the fusion of four enzymatic domains that initiate the de novo biosynthesis of pyrimidine nucleotides . The first two domains, glutaminase (GLN) and carbamoyl phosphate synthetase (CPS-II), initiate the pathway, catalyzing the formation of carbamoyl phosphate (CP) from bicarbonate, glutamine, and two ATP molecules. Next, the labile CP is partially channeled to the C-terminal aspartate transcarbamoylase (ATC) domain where it reacts with aspartate to form carbamoyl aspartate. Then, carbamoyl aspartate is condensated to dihydroorotate, the cyclic precursor of the pyrimidine ring, by the dihydroorotase (DHO), a Zn metalloenzyme fused between CPS and ATC domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a5-b1-g2) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264926 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
hydrogencarbonate