| + |
ATF4 | up-regulates quantity by expression 
transcriptional regulation
|
SARS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269424 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33384352 |
QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 and ATF4 modulate tRNA metabolic processes to promote secreted protein synthesis during ER stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SARS1 | down-regulates activity 
binding
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259368 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24940000 |
Using in vitro, cell and animal experiments, we show here that SerRS intervenes by antagonizing c-Myc, the major transcription factor promoting VEGFA expression, through a tandem mechanism. First, by direct head-to-head competition, nuclear-localized SerRS blocks c-Myc from binding to the VEGFA promoter. Second, DNA-bound SerRS recruits the SIRT2 histone deacetylase to erase prior c-Myc-promoted histone acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SARS1 | up-regulates quantity
chemical modification
|
AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24095058 |
As a member of the aminoacyl-tRNA synthetase family, seryl-tRNA synthetase (SerRS) catalyzes the aminoacylation reaction that charges serine onto its cognate tRNA for protein synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SARS1 | up-regulates quantity
chemical modification
|
Ser-tRNA(Ser) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270498 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24095058 |
As a member of the aminoacyl-tRNA synthetase family, seryl-tRNA synthetase (SerRS) catalyzes the aminoacylation reaction that charges serine onto its cognate tRNA for protein synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Translation elongation and termination |
| + |
SARS1 | up-regulates quantity
chemical modification
|
alpha-aminoacyl-tRNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270800 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14660560 |
Aminoacyl-tRNA synthetases (aaRSs)1 are a family of ancient enzymes that catalyze amino acid activation by ATP and the subsequent aminoacylation to its cognate tRNA. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270802 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14660560 |
Aminoacyl-tRNA synthetases (aaRSs)1 are a family of ancient enzymes that catalyze amino acid activation by ATP and the subsequent aminoacylation to its cognate tRNA. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Translation elongation and termination |
| + |
SARS1 | down-regulates quantity
chemical modification
|
tRNA(Ser) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270493 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24095058 |
As a member of the aminoacyl-tRNA synthetase family, seryl-tRNA synthetase (SerRS) catalyzes the aminoacylation reaction that charges serine onto its cognate tRNA for protein synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SARS1 | down-regulates quantity
chemical modification
|
ATP(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270495 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24095058 |
As a member of the aminoacyl-tRNA synthetase family, seryl-tRNA synthetase (SerRS) catalyzes the aminoacylation reaction that charges serine onto its cognate tRNA for protein synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SARS1 | down-regulates quantity
chemical modification
|
serine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270494 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24095058 |
As a member of the aminoacyl-tRNA synthetase family, seryl-tRNA synthetase (SerRS) catalyzes the aminoacylation reaction that charges serine onto its cognate tRNA for protein synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SARS1 | up-regulates quantity
chemical modification
|
diphosphate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270496 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24095058 |
As a member of the aminoacyl-tRNA synthetase family, seryl-tRNA synthetase (SerRS) catalyzes the aminoacylation reaction that charges serine onto its cognate tRNA for protein synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SARS1
- 
- 