Summary

Name ACADVL
Full Name Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Synonyms VLCAD | VLCAD
Primary ID P49748
Links - -
Type protein
Relations 5
Pathways Fatty Acid Beta-Oxidation
Function Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:7668252, PubMed:9461620, PubMed:18227065, PubMed:9839948, PubMed:9599005). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:7668252, PubMed:9461620, PubMed:18227065, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKACAup-regulates activity img/direct-activation.png phosphorylation ACADVL 0.2
Publications: 1 Organism: In Vitro
+ ACADVLdown-regulates quantity img/direct_inhibition.png chemical modification palmitoyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADVLdown-regulates quantity img/direct_inhibition.png chemical modification FAD(3-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADVLup-regulates quantity img/direct-activation.png chemical modification (E)-hexadec-2-enoyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADVLup-regulates quantity img/direct-activation.png chemical modification FADH2(2-) 0.8
Publications: 1 Organism: Homo Sapiens