Summary

Name RGS7
Full Name Regulator of G-protein signaling 7
Synonyms RGS7 |
Primary ID P49802
Links - -
Type protein
Relations 1
Function Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation RGS7 0.371
Publications: 1 Organism: In Vitro