Relation Results

Summary

Name LIG3
Full Name DNA ligase 3
Synonyms DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3
Primary ID P49916
Links - -
Type protein
Relations 1
Function Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid ...
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Type: Score: Layout: SPV 
0.422CDK2LIG3

Modifications Tables

Relations

Regulator
Mechanism
target
score
+ down-regulates img/direct_inhibition.png phosphorylation LIG3 0.422
Identifier Residue Sequence Organism Cell Line
SIGNOR-150121 Ser210 TTTGQVTsPVKGASF Homo sapiens
pmid sentence
Dna ligase iii_ is specifically phosphorylated in replicating cells by the cell cycle kinase cdk2. However, in response to oxidative dna damage, dna ligase iii_ is dephosphorylated in a pathway that is dependent upon the dna damage-activated, phosphatidylinositol 3-phosphate (pi3)1-related kinase atm.
Publications: 1 Organism: Homo Sapiens
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