Summary

Name MEOX2
Full Name Homeobox protein MOX-2
Synonyms Growth arrest-specific homeobox, Mesenchyme homeobox 2 | GAX, MOX2
Primary ID P50222
Links - -
Type protein
Relations 5
Function Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MEOX2 0.326
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png MEOX2 0.4
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MEOX2 0.421
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding MEOX2 0.414
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding MEOX2 0.384
Publications: 1 Organism: Mus Musculus