| + |
GSK3B | up-regulates quantity 
phosphorylation
|
PAX3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278482 |
Ser197 |
GILSERAsAPQSDEG |
Homo sapiens |
|
| pmid |
sentence |
| 22679108 |
The ubiquitously expressed CK2 often provides the priming phosphorylation for GSK-3, however, we found that GSK-3beta alone was sufficient to phosphorylate PAX3 at both Ser205 and Ser197 and Ser201 in-vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278481 |
Ser201 |
ERASAPQsDEGSDID |
Homo sapiens |
|
| pmid |
sentence |
| 22679108 |
The ubiquitously expressed CK2 often provides the priming phosphorylation for GSK-3, however, we found that GSK-3beta alone was sufficient to phosphorylate PAX3 at both Ser205 and Ser197 and Ser201 in-vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278483 |
Ser205 |
APQSDEGsDIDSEPD |
Homo sapiens |
|
| pmid |
sentence |
| 22679108 |
The ubiquitously expressed CK2 often provides the priming phosphorylation for GSK-3, however, we found that GSK-3beta alone was sufficient to phosphorylate PAX3 at both Ser205 and Ser197 and Ser201 in-vitro. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
BRAF | up-regulates activity
phosphorylation
|
PAX3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278435 |
Ser205 |
APQSDEGsDIDSEPD |
Homo sapiens |
|
| pmid |
sentence |
| 27906130 |
BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development.|We found that BRAF clearly induced phosphorylation of PAX3 at Ser205 in both cell types (XREF_FIG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
CDK4 | up-regulates activity
phosphorylation
|
PAX3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278512 |
Ser430 |
TTVSASCsQRLDHMK |
Homo sapiens |
|
| pmid |
sentence |
| 23469153 |
In summary, our study showed that Cdk4 phosphorylates and activates PAX3-FOXO1, thereby promoting its oncogenic function.|These findings suggest that Cdk4 phosphorylates the Ser 430 residue of PAX3-FOXO1 in vitro . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAD23B | down-regulates activity 
binding
|
PAX3 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-237667 |
|
|
in vitro |
|
| pmid |
sentence |
| 17662948 |
Monoubiquitinated Pax3 was shuttled to the intrinsic proteasomal protein S5a by interacting specifically with the ubiquitin-binding protein Rad23B. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PAX3 | up-regulates quantity by expression
transcriptional regulation
|
TBX2 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249596 |
|
|
Homo sapiens |
Rhabdomyosarcoma Cell Line |
| pmid |
sentence |
| 25211658 |
We have recently found that a T-box gene family member, TBX2, is highly overexpressed in both ERMS and ARMS cells (Zhu et al, 2014). The regulation of TBX2 is uncharacterised in RMS cells, but is likely to link TBX2 expression to the known deregulation of signalling pathways in RMS. In melanoma cells, TBX2 is regulated by PAX3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
PAX3 | up-regulates activity
binding
|
LEF1 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20006729 |
Pax3 binds to lef1 pax3 activity may directly effect the expression of factors regulated by signal transduction pathways dependent on lef1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling and Myogenesis |
| + |
PAX3 | up-regulates quantity by expression 
transcriptional regulation
|
MYOD1 |
0.493 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181621 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 18854138 |
Our cell-based assays and in vitro studies reveal a tight codependent partnership between foxo3 and pax3/7 to coordinately recruit rna polymerase ii and form a preinitiation complex (pic) to activate myod transcription in myoblasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma, WNT Signaling and Myogenesis |
| + |
WWTR1 | up-regulates
binding
|
PAX3 |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236879 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 16300735 |
These results indicate that pax3 specifically interacts with taz both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PAX3 | up-regulates activity
binding
|
MEOX2 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222238 |
|
|
in vitro |
|
| pmid |
sentence |
| 11423130 |
We show that Mox1 and Mox2 proteins are capable of interacting with Pax1 and Pax3. We propose that the Mox family of homeodomain proteins participates in the molecular signaling network regulating the diverse events of somite development through the physical interaction with the Pax1 and Pax3 members of the Pax family. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PAX3 | up-regulates activity
binding
|
MEOX1 |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222235 |
|
|
in vitro |
|
| pmid |
sentence |
| 11423130 |
We show that Mox1 and Mox2 proteins are capable of interacting with Pax1 and Pax3. We propose that the Mox family of homeodomain proteins participates in the molecular signaling network regulating the diverse events of somite development through the physical interaction with the Pax1 and Pax3 members of the Pax family. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PAX3 | up-regulates quantity by expression
transcriptional regulation
|
FGFR4 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251572 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25211658 |
FGFR4 is a transcriptional target of PAX3 and the PAX3-FOXO1 fusion protein found in ARMS. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
PAX3 |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Chen et al. showed that phosphorylated creb is present at high levels in cells of the dermomyotome that express pax3, myod and myf5 and that this phosphorylation is critical for the induction of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
PAX3 | up-regulates quantity by expression
transcriptional regulation
|
PITX2 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170343 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21143873 |
Pitx genes, such as pitx2, which is positively regulated by pax3, have been implicated in myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling and Myogenesis |
| + |
PAX3 | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.486 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200862 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23384562 |
Direct molecular regulation of the myogenic determination gene myf5 by pax3, with modulation by six1/4 factors, is exemplified by the -111 kb-myf5 enhancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | WNT Signaling and Myogenesis |
3.0
PAX3
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