+ |
CSNK2A1 | up-regulates activity
phosphorylation
|
CAV2 |
0.325 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-101106 |
Ser23 |
DDSYSHHsGLEYADP |
Homo sapiens |
Prostate Gland Cancer Cell |
pmid |
sentence |
12743374 |
We show that caveolin-2 is phosphorylated in vivo at two serine residues and that the phosphorylation of caveolin-2 is necessary for its actions as a positive regulator of caveolin-1 during organelle biogenesis in prostate cancer cells. Mutation of the primary phosphorylation sites on caveolin-2, serine 23 and 36, reduces the number of plasmalemma-attached caveolae |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-101110 |
Ser36 |
DPEKFADsDQDRDPH |
Homo sapiens |
Prostate Gland Cancer Cell |
pmid |
sentence |
12743374 |
We show that caveolin-2 is phosphorylated in vivo at two serine residues and that the phosphorylation of caveolin-2 is necessary for its actions as a positive regulator of caveolin-1 during organelle biogenesis in prostate cancer cells. Mutation of the primary phosphorylation sites on caveolin-2, serine 23 and 36, reduces the number of plasmalemma-attached caveolae |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
SRC | down-regulates
phosphorylation
|
CAV2 |
0.667 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-90225 |
Tyr19 |
LFMDDDSySHHSGLE |
Homo sapiens |
|
pmid |
sentence |
12091389 |
We show that caveolin-2 undergoes src-induced phosphorylation on tyrosine 19. we conclude that the tyrosine phosphorylation of caveolin-2 (tyr(p)(19)) may function as a signal that is recognized by the cellular machinery to induce the dissociation of caveolin-2 from caveolin-1 oligomers |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-129961 |
Tyr27 |
SHHSGLEyADPEKFA |
Homo sapiens |
|
pmid |
sentence |
15504032 |
Here, we show that cav-2 is phosphorylated at both tyrosines 19 and 27. We reconstituted this phosphorylation event by recombinantly coexpressing c-src and cav-2.Further functional analysis revealed that tyrosine phosphorylation of cav-2 has no effect on its targeting to lipid rafts, but clearly disrupts the hetero-oligomerization of cav-2 with cav-1. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |