Summary

Name UBE2D1
Full Name Ubiquitin-conjugating enzyme E2 D1
Synonyms (E3-independent) E2 ubiquitin-conjugating enzyme D1, 2.3.2.24, E2 ubiquitin-conjugating enzyme D1, Stimulator of Fe transport, SFT, UBC4/5 homolog, UbcH5, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2(17)KB 1, Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase D1 | SFT, UBC5A, UBCH5, UBCH5A
Primary ID P51668
Links - -
Type protein
Relations 11
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding Elongin E3-Cul-5 0.592
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png ubiquitination PEX5 0.401
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png ubiquitination UBE2D1 0.826
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination UBE2D1 0.708
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding UBE2D1 0.609
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding MPG 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding ZSWIM2 0.326
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination TRIM65 0.305
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MGRN1 0.467
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TRIM2 0.281
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding KPC 0.448
Publications: 1 Organism: Mus Musculus