+ |
NR0B1 | down-regulates activity
binding
|
NR5A1 |
0.726 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271784 |
|
|
Homo sapiens |
NCI-H295R Cell |
pmid |
sentence |
19237537 |
The in vivo existence of an SF-1 corepressor complex consisting of DAX-1, RNF31, and SMRT at the steroidogenic promoters of the human StAR and CYP19 genes. We demonstrate that RNF31 is necessary for the stable association of the DAX-1 corepressor complex with chromatin-bound SF-1, thereby inhibiting the recruitment of coactivators and Pol II and controlling basal transcription levels of SF-1 target genes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RNF31 | up-regulates quantity by stabilization
monoubiquitination
|
NR0B1 |
0.449 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271786 |
|
|
Homo sapiens |
NCI-H295R Cell |
pmid |
sentence |
19237537 |
RNF31 promotes monoubiquitination of DAX-1 in an RBR domain-dependent manner. In conclusion, our results suggest that the major DAX-1 modification observed in different experimental settings is likely to be monoubiquitination at one or more lysine residues (multiubiquitination) possibly located within the LBD of DAX-1. RNF31 stabilizes endogenous DAX-1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ESRRB | down-regulates
|
NR0B1 |
0.35 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-96533 |
|
|
Homo sapiens |
|
pmid |
sentence |
12482977 |
When dax-1 was cotransfected, it exerted efficient repression on transcription of the reporter gene activated by gal4-ad4bp-lbd, gal4-lrh-1-lbd, gal4-err2-lbd |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NR0B1 | up-regulates activity
binding
|
NCOR2 |
0.402 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271785 |
|
|
Homo sapiens |
NCI-H295R Cell |
pmid |
sentence |
19237537 |
The in vivo existence of an SF-1 corepressor complex consisting of DAX-1, RNF31, and SMRT at the steroidogenic promoters of the human StAR and CYP19 genes. We demonstrate that RNF31 is necessary for the stable association of the DAX-1 corepressor complex with chromatin-bound SF-1, thereby inhibiting the recruitment of coactivators and Pol II and controlling basal transcription levels of SF-1 target genes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |