Summary

Name NCOR2
Full Name Nuclear receptor corepressor 2
Synonyms N-CoR2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, SMRT, T3 receptor-associating factor, TRAC, Thyroid-, retinoic-acid-receptor-associated corepressor | CTG26
Primary ID Q9Y618
Links - -
Type protein
Relations 13
Function Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation NCOR2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOR2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOR2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOR2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BHLHE41 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png acetylation PGR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BCL6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png NCOR2 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NCOR2 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding SPEN 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png acetylation AR 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SNW1 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG 0.14
Publications: 1 Organism: Homo Sapiens