+ |
FYN | down-regulates activity
phosphorylation
|
CNN1 |
0.338 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251157 |
Tyr182 |
SQQGMTAyGTRRHLY |
Chlorocebus aethiops |
|
pmid |
sentence |
15206927 |
We identify, for the first time, tyrosine-phosphorylated calponin h3 within COS 7 cells, before and after their transfection with the pSV vector containing cDNA encoding the cytoplasmic, Src-related, tyrosine kinase, Fyn. we have localized the tyrosines phosphorylated without actin to Tyr261 in calponin h3 and to Tyr261 and Tyr182 in calponin h1. Tyrosine phosphorylation of calponins inhibits their binding to F-actin |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251158 |
Tyr261 |
SQRGMTVyGLPRQVY |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
15206927 |
We identify, for the first time, tyrosine-phosphorylated calponin h3 within COS 7 cells, before and after their transfection with the pSV vector containing cDNA encoding the cytoplasmic, Src-related, tyrosine kinase, Fyn. we have localized the tyrosines phosphorylated without actin to Tyr261 in calponin h3 and to Tyr261 and Tyr182 in calponin h1. Tyrosine phosphorylation of calponins inhibits their binding to F-actin |
|
Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
+ |
SRF | up-regulates quantity by expression
transcriptional regulation
|
CNN1 |
0.371 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-174358 |
|
|
Homo sapiens |
|
pmid |
sentence |
21673106 |
In particular, high expression of vsmc-specific genes, such as smooth muscle -actin (sma), calponin1 (cnn), and sm22 (sm22) are associated with the contractile vsmc phenotype. Transcription of contractile genes is regulated by srf through a dna sequence motif known as the carg box (cc(a/t)6gg), which is present in the promoters of vsmc-specific genes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Muscle, Smooth Muscle |