+ |
PKA | down-regulates activity
phosphorylation
|
MYOM1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263156 |
Ser618 |
ARLKSRPsAPWTGQI |
in vitro |
|
pmid |
sentence |
9029142 |
This interaction is regulated by phosphorylation of Ser482 in the linker between myomesin domains My4 and My5. Myomesin phosphorylation at this site by cAMP-dependent kinase and similar or identical activities in muscle extracts block the association with titin. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
MYOM1 | up-regulates quantity
relocalization
|
OBSCN |
0.304 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266727 |
|
|
Homo sapiens |
Cardiomyocyte Cell Line |
pmid |
sentence |
19840192 |
Ankyrin-B is targeted to the M-line via its interaction with the C-terminal domain of the large sarcomeric protein obscurin. Obscurin is targeted to the M-line via its N-terminal interactions with myomesin and titin. This population of ankyrin-B recruits B56α, a regulatory subunit of protein phosphatase 2A, to the M-line where the phosphatase may regulate the phosphorylation status of contractile and signalling proteins. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |