4.0
Summary
| Name |  OBSCN
|
| Full Name | Obscurin |
| Synonyms | Obscurin-RhoGEF, Obscurin-myosin light chain kinase, Obscurin-MLCK | KIAA1556, KIAA1639 |
| Primary ID | Q5VST9 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TTN | up-regulates quantity 
relocalization
|
OBSCN | 0.577 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OBSCN | up-regulates quantity
relocalization
|
ANK2 | 0.497 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MYOM1 | up-regulates quantity
relocalization
|
OBSCN | 0.3 |
| Publications: | 1 | Organism: | Homo Sapiens | |