Relation Results

Name	MSH6
Full Name	DNA mismatch repair protein Msh6
Synonyms	hMSH6, G/T mismatch-binding protein, GTBP, GTMBP, MutS protein homolog 6, MutS-alpha 160 kDa subunit, p160 \| GTBP
Primary ID	P52701
Links	- -
Type	protein
Relations	2
Function	Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch