Relation Results

Summary

Name BLM
Full Name Bloom syndrome protein
Synonyms DNA helicase, RecQ-like type 2, RecQ2, RecQ protein-like 3 | RECQ2, RECQL3
Primary ID P54132
Links - -
Type protein
Relations 18
Function ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030). Parti ...
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Type: Score: Layout: SPV 
0.4270.260.7790.5370.7730.2820.6060.330.2630.2760.5970.5880.6520.3390.7CyclinA2/CDK2BLMGSK3BCHEK1CHEK2ATMMIB1MSH6UIMC1RNF168SCF-FBW7MSH2/MSH6MSH2BRIP1RNF8DNA_repair

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CyclinA2/CDK2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BLM 0.427
Identifier Residue Sequence Organism Cell Line
SIGNOR-276910 Ser175 SFVTPPQsHFVRVST Homo sapiens HEK-293T Cell
pmid sentence
We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence which is conserved in all primates.
Identifier Residue Sequence Organism Cell Line
SIGNOR-276907 Thr171 ETSKSFVtPPQSHFV Homo sapiens HEK-293T Cell
pmid sentence
We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence which is conserved in all primates.
Publications: 2 Organism: Homo Sapiens
+ GSK3Bdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BLM 0.26
Identifier Residue Sequence Organism Cell Line
SIGNOR-276911 Ser175 SFVTPPQsHFVRVST Homo sapiens HEK-293T Cell
pmid sentence
We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence which is conserved in all primates.
Identifier Residue Sequence Organism Cell Line
SIGNOR-276906 Thr171 ETSKSFVtPPQSHFV Homo sapiens HEK-293T Cell
pmid sentence
We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence which is conserved in all primates.
Publications: 2 Organism: Homo Sapiens
+ CHEK1up-regulates img/direct-activation.png phosphorylation BLM 0.779
Identifier Residue Sequence Organism Cell Line
SIGNOR-167534 Ser646 LKHERFQsLSFPHTK Homo sapiens
pmid sentence
Hese results indicated that chk1-mediated phosphorylation on blm at ser(646) might be a determinant for regulating subnuclear localization and could act as a marker for the activation status of blm in response to dna damage.
Publications: 1 Organism: Homo Sapiens
+ CHEK1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BLM 0.779
Identifier Residue Sequence Organism Cell Line
SIGNOR-276909 Thr182 SHFVRVStAQKSKKG Homo sapiens HEK-293T Cell
pmid sentence
We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence which is conserved in all primates.Phosphorylation on BLM Thr171 and Ser175 depends on prior phosphorylation at Thr182 by Chk1/Chk2. Thr182 phosphorylation not only controls BLM ubiquitylation and degradation during mitosis but is also a determinant for its localization on the ultrafine bridges.
Publications: 1 Organism: Homo Sapiens
+ CHEK2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BLM 0.537
Identifier Residue Sequence Organism Cell Line
SIGNOR-276908 Thr182 SHFVRVStAQKSKKG Homo sapiens HEK-293T Cell
pmid sentence
We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence which is conserved in all primates.Phosphorylation on BLM Thr171 and Ser175 depends on prior phosphorylation at Thr182 by Chk1/Chk2. Thr182 phosphorylation not only controls BLM ubiquitylation and degradation during mitosis but is also a determinant for its localization on the ultrafine bridges.
Publications: 1 Organism: Homo Sapiens
+ ATMup-regulates img/direct-activation.png phosphorylation BLM 0.773
Identifier Residue Sequence Organism Cell Line
SIGNOR-88010 Thr99 NAPAGQEtQRGGSKS Homo sapiens
pmid sentence
Mitotic phosphorylation of blm was partially dependent on atm, and phosphorylation sites on blm were identified. A phosphospecific antibody against one of these sites (thr-99) revealed radiation-induced phosphorylation, which was defective in ataxia-telangiectasia cells. These data suggest that atm and blm function together in recognizing abnormal dna structures by direct interaction and that these phosphorylation sites in blm are important for radiosensitivity status but not for sce frequency.
Publications: 1 Organism: Homo Sapiens
+ MIB1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination BLM 0.282
Identifier Residue Sequence Organism Cell Line
SIGNOR-278548 Homo sapiens
pmid sentence
BLM is Ubiquitinated by E3 Ligase MIB1.|Moreover, MIB1 mediated BLM degradation in G1 phase appears to be important for DNA double-strand break repair.
Publications: 1 Organism: Homo Sapiens
+ MSH6up-regulates img/direct-activation.png binding BLM 0.606
Identifier Residue Sequence Organism Cell Line
SIGNOR-123705 Homo sapiens
pmid sentence
We show that the recombinant hmsh2/6 protein complex stimulated the ability of the bloom's syndrome gene product, blm, to process holliday junctions in vitro
Publications: 1 Organism: Homo Sapiens
+ BLMup-regulates activity img/direct-activation.png binding UIMC1 0.33
Identifier Residue Sequence Organism Cell Line
SIGNOR-272116 Homo sapiens U2-OS Cell
pmid sentence
Here, we demonstrate that the ubiquitin/SUMO-dependent DNA damage response (UbS-DDR), controlled by the E3 ligases RNF8/RNF168, triggers BLM recruitment to sites of replication fork stalling via ubiquitylation in the N-terminal region of BLM and subsequent BLM binding to the ubiquitin-interacting motifs of . 
Publications: 1 Organism: Homo Sapiens
+ RNF168up-regulates activity img/direct-activation.png ubiquitination BLM 0.263
Identifier Residue Sequence Organism Cell Line
SIGNOR-272114 Homo sapiens U2-OS Cell
pmid sentence
Here, we demonstrate that the ubiquitin/SUMO-dependent DNA damage response (UbS-DDR), controlled by the E3 ligases RNF8/RNF168, triggers BLM recruitment to sites of replication fork stalling via ubiquitylation in the N-terminal region of BLM and subsequent BLM binding to the ubiquitin-interacting motifs of RAP80. 
Publications: 1 Organism: Homo Sapiens
+ SCF-FBW7down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination BLM 0.276
Identifier Residue Sequence Organism Cell Line
SIGNOR-276912 Homo sapiens HEK-293T Cell
pmid sentence
We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence which is conserved in all primates.
Publications: 1 Organism: Homo Sapiens
+ MSH2/MSH6up-regulates img/direct-activation.png binding BLM 0.597
Identifier Residue Sequence Organism Cell Line
SIGNOR-217223 Homo sapiens
pmid sentence
We show that the recombinant hmsh2/6 protein complex stimulated the ability of the bloom's syndrome gene product, blm, to process holliday junctions in vitro
Publications: 1 Organism: Homo Sapiens
+ MSH2up-regulates img/direct-activation.png binding BLM 0.588
Identifier Residue Sequence Organism Cell Line
SIGNOR-123699 Homo sapiens
pmid sentence
We show that the recombinant hmsh2/6 protein complex stimulated the ability of the bloom's syndrome gene product, blm, to process holliday junctions in vitro
Publications: 1 Organism: Homo Sapiens
+ BRIP1up-regulates quantity by stabilization img/direct-activation.png binding BLM 0.652
Identifier Residue Sequence Organism Cell Line
SIGNOR-259186 Homo sapiens HeLa Cell
pmid sentence
In this work, FANCJ and BLM were found to interact physically and functionally in human cells and co-localize to nuclear foci in response to replication stress. The cellular level of BLM is strongly dependent upon FANCJ, and BLM is degraded by a proteasome-mediated pathway when FANCJ is depleted.
Publications: 1 Organism: Homo Sapiens
+ RNF8up-regulates activity img/direct-activation.png ubiquitination BLM 0.339
Identifier Residue Sequence Organism Cell Line
SIGNOR-272115 Homo sapiens U2-OS Cell
pmid sentence
Here, we demonstrate that the ubiquitin/SUMO-dependent DNA damage response (UbS-DDR), controlled by the E3 ligases RNF8/RNF168, triggers BLM recruitment to sites of replication fork stalling via ubiquitylation in the N-terminal region of BLM and subsequent BLM binding to the ubiquitin-interacting motifs of . 
Publications: 1 Organism: Homo Sapiens
+ BLMup-regulates img/indirect-activation.png DNA_repair 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261824 Homo sapiens
pmid sentence
The BLM gene product, BLM, is a RECQ helicase that is involved in DNA replication and repair of DNA double-strand breaks by the homologous recombination (HR) pathway. During HR, BLM has both pro- and anti-recombinogenic activities, either of which may contribute to maintenance of genomic integrity.
Publications: 1 Organism: Homo Sapiens
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