| + |
KMN network | up-regulates 
|
Spindle_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18007590 |
Based on our results, we propose that the cooperative action of CENP-A NAC/CAD subunits and the KMN network drives efficient chromosome segregation and bipolar spindle assembly during mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cytoplasmic_Dynein | up-regulates
|
Spindle_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265059 |
|
|
|
|
| pmid |
sentence |
| 16440056 |
The most abundant cytoplasmic dynein complex, cytoplasmic dynein 1, is involved in functions as diverse as spindle-pole organization and nuclear migration during mitosis, the positioning and functioning of the endoplasmic reticulum, the Golgi apparatus, and the nucleus, and also the minus-end-directed transport of vesicles, including endosomes and lysosomes, along microtubules and retrograde axonal transport in neurons. |
|
| Publications: |
1 |
| + |
CCAN complex | up-regulates
|
Spindle_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265214 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18007590 |
Based on our results, we propose that the cooperative action of CENP-A NAC/CAD subunits and the KMN network drives efficient chromosome segregation and bipolar spindle assembly during mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CENPE | up-regulates
|
Spindle_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252013 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Additionally, cdr2 knockdown lead to a decrease (Table 3) in four other transcripts (AURKA, CENPE, SPC25 and TTK), which are involved in kinetochore and spindle biology |
|
| Publications: |
1 |
| + |
KIF11 | up-regulates
|
Spindle_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265098 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21969468 |
The C-terminal fragment interferes with the TPX2–Eg5 interaction, relieving the inhibition of TPX2 on Eg5 and generating the observed spindle lengthening. According to this model, TPX2 and Eg5 should localize to microtubules in the spindle midzone. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRC1 | up-regulates
|
Spindle_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265987 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15297875 |
These results suggest that KIF4 and its binding partner PRC1 play essential roles in the organization of central spindles and midzone formation. KIF4 deficiency leads to mislocalization of PRC1, MKLP1, CENP-E and chromosomal passenger proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIF4A | up-regulates
|
Spindle_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265986 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15297875 |
These results suggest that KIF4 and its binding partner PRC1 play essential roles in the organization of central spindles and midzone formation. KIF4 deficiency leads to mislocalization of PRC1, MKLP1, CENP-E and chromosomal passenger proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Spindle_assembly