Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250060 |
Ser643 |
KVGMDYRsCILRPGG |
in vitro |
|
pmid |
sentence |
10969067 |
PKA phosphorylation is suggested to play a regulatory role in EP24.15 enzyme activity. Mutation analysis of each putative PKA site, in vitro phosphorylation, and phosphopeptide mapping indicated serine 644 as the phosphorylation site. The most dramatic change upon PKA phosphorylation was a substrate-specific, 7-fold increase in both K(m) and k(cat) for GnRH. |
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