3.0
Summary
| Name |  ATXN3View Modifications |
| Full Name | Ataxin-3 |
| Synonyms | Machado-Joseph disease protein 1, Spinocerebellar ataxia type 3 protein | ATX3, MJD, MJD1, SCA3 |
| Primary ID | P54252 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | up-regulates activity 
phosphorylation
|
ATXN3 | 0.2 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | GSK3B | up-regulates quantity by stabilization
phosphorylation
|
ATXN3 | 0.475 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STUB1 | down-regulates quantity by destabilization 
ubiquitination
|
ATXN3 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UBE4B | down-regulates quantity by destabilization
polyubiquitination
|
ATXN3 | 0.592 |
| Publications: | 1 | Organism: | Homo Sapiens | |