| + |
PRKDC | up-regulates activity 
phosphorylation
|
PRKAG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277503 |
Ser192 |
KPEFMSKsLEELQIG |
in vitro |
|
| pmid |
sentence |
| 31983282 |
PRKDC interacted with the AMPK complex and phosphorylated its nucleotide-sensing γ1 subunit PRKAG1/AMPKγ1 at Ser192 and Thr284, both events being significantly reduced upon the activation of the AMPK complex. Alanine substitutions of PRKDC phosphorylation sites in PRKAG1 reduced AMPK complex activation without affecting its nucleotide sensing capacity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277504 |
Thr284 |
LKCYLHEtLETIINR |
in vitro |
|
| pmid |
sentence |
| 31983282 |
PRKDC interacted with the AMPK complex and phosphorylated its nucleotide-sensing γ1 subunit PRKAG1/AMPKγ1 at Ser192 and Thr284, both events being significantly reduced upon the activation of the AMPK complex. Alanine substitutions of PRKDC phosphorylation sites in PRKAG1 reduced AMPK complex activation without affecting its nucleotide sensing capacity. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
ADP | up-regulates
chemical activation
|
PRKAG1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21399626 |
Amp binding to the gamma-regulatory domain promotes phosphorylation by the upstream kinase, protects the enzyme against dephosphorylation, as well as causing allosteric activation.Adp also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. Atp promotes dephosphorylation of catalytic subunit, rendering the ampk enzyme inactive. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP | down-regulates 
chemical inhibition
|
PRKAG1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21680840 |
AMPK is an ___ heterotrimer activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172822 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21399626 |
Atp promotes dephosphorylation of catalytic subunit, rendering the ampk enzyme inactive |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKAG1 | form complex 
binding
|
AMPK |
0.755 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139170 |
|
|
Homo sapiens |
Adipocyte |
| pmid |
sentence |
| 16054041 |
Gamma non-catalytic subunit mediates binding to amp, adp and atp, leading to activate or inhibit ampk: amp-binding results in allosteric activation of alpha catalytic subunit (prkaa1 or prkaa2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle, Brain, Heart, Liver |
| + |
PRKAG1 | up-regulates
binding
|
PRKAA2 |
0.893 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139173 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16054041 |
Gamma non-catalytic subunit mediates binding to amp, adp and atp, leading to activate or inhibit ampk: amp-binding results in allosteric activation of alpha catalytic subunit (prkaa1 or prkaa2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
acadesine | up-regulates
chemical activation
|
PRKAG1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148337 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16879084 |
The activation of the ampk pathway by exendin-4 was induced by aicar, which was inhibited by compound c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PRKAG1
- 
- 