| + |
HNF1B | up-regulates quantity by expression
transcriptional regulation
|
FXYD2 |
0.293 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251927 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19389850 |
We analyzed genes associated with hypermagnesuria and detected highly conserved HNF1 recognition sites in FXYD2, a gene that can cause autosomal dominant hypomagnesemia and hypocalciuria when mutated. Using a luciferase reporter assay, we demonstrated HNF1B-mediated transactivation of FXYD2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254909 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24204001 |
Overexpression in a human kidney cell line showed that wild-type PCBD1 binds HNF1B to costimulate the FXYD2 promoter, the activity of which is instrumental in Mg(2+) reabsorption in the DCT. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Renal Distal Tubule |
| + |
PCBD1 | up-regulates quantity by expression
transcriptional regulation
|
FXYD2 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254908 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24204001 |
Overexpression in a human kidney cell line showed that wild-type PCBD1 binds HNF1B to costimulate the FXYD2 promoter, the activity of which is instrumental in Mg(2+) reabsorption in the DCT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Renal Distal Tubule |