Relation Results

Summary

Name PCBD1
Full Name Pterin-4-alpha-carbinolamine dehydratase
Synonyms PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Dimerization cofactor of hepatocyte nuclear factor 1-alpha, DCoH, Dimerization cofactor of HNF1, Phenylalanine hydroxylase-stimulating protein, Pterin carbinolamine dehydratase, PCD | DCOH, PCBD
Primary ID P61457
Links - -
Type protein
Relations 2
Function Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactiva ...
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Type: Score: Layout: SPV 
0.3520.591PCBD1FXYD2HNF1B

Relations

Regulator
Mechanism
target
score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FXYD2 0.352
Identifier Residue Sequence Organism Cell Line
SIGNOR-254908 Homo sapiens
pmid sentence
Overexpression in a human kidney cell line showed that wild-type PCBD1 binds HNF1B to costimulate the FXYD2 promoter, the activity of which is instrumental in Mg(2+) reabsorption in the DCT.
Publications: 1 Organism: Homo Sapiens
Tissue: Renal Distal Tubule
+ up-regulates activity img/direct-activation.png binding HNF1B 0.591
Identifier Residue Sequence Organism Cell Line
SIGNOR-254910 Homo sapiens
pmid sentence
Overexpression in a human kidney cell line showed that wild-type PCBD1 binds HNF1B to costimulate the FXYD2 promoter, the activity of which is instrumental in Mg(2+) reabsorption in the DCT.
Publications: 1 Organism: Homo Sapiens
Tissue: Renal Distal Tubule
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