+ |
EPHB3 | down-regulates activity
phosphorylation
|
CDKN1B |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279406 |
Thr187 |
NAGSVEQtPKKPGLR |
Homo sapiens |
|
pmid |
sentence |
10389236 |
In accord with this concept are the findings of Vlach et al. , who have studied point mutants of p27 deficient in their interactions with EK2, and have found that T187 phosphorylation of p27 by EK2 requires an interaction of p27 with the cyclin E subunit, while inhibition of the kinase activity requires an additional interaction with the CDK2 subunit.|The question considered here is the theoretical question whether deactivation of p27 by EK2 can produce binary EK2 release, and if so what biochemical kinetic features are required for this behavior. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EPHB3 | up-regulates activity
phosphorylation
|
EPHB3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251126 |
Tyr614 |
VYIDPFTyEDPNEAV |
in vitro |
|
pmid |
sentence |
9674711 |
Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. a single amino acid substitution (Y614F) clearly reduces the phosphotyrosine content of HEK2 and abrogates its ability to bind rasGAP, Crk and Fyn indicating that this residue functions as major phosphorylation and multi-docking site. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
EFNB2 | up-regulates
binding
|
EPHB3 |
0.882 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-52583 |
|
|
Homo sapiens |
|
pmid |
sentence |
9330863 |
Lerk-5 is a ligand for both elk and hek and induces receptor phosphorylation |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-39862 |
|
|
Homo sapiens |
|
pmid |
sentence |
8559144 |
Lerk-5 is a ligand for both elk and hek and induces receptor phosphorylation |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
EFNB1 | up-regulates
binding
|
EPHB3 |
0.76 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-52517 |
|
|
Homo sapiens |
|
pmid |
sentence |
9330863 |
The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EFNB3 | up-regulates
binding
|
EPHB3 |
0.82 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-54711 |
|
|
Homo sapiens |
|
pmid |
sentence |
9484836 |
Ephrin-b3, a ligand for the receptor ephb3, expressed at the midline of the developing neural tube. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-52624 |
|
|
Homo sapiens |
|
pmid |
sentence |
9330863 |
Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). In either case, binding of a ligand results in eph receptor autophosphorylation on tyrosine residues and activation of the kinase activity of the eph receptor |
|
Publications: |
2 |
Organism: |
Homo Sapiens |