Relation Results

Summary

Name NRL
Full Name Neural retina-specific leucine zipper protein
Synonyms NRL | D14S46E
Primary ID P54845
Links - -
Type protein
Relations 3
Function Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions ...
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Type: Score: Layout: SPV 
0.4480.3770.556NRLRHORBP3FIZ1

Relations

Regulator
Mechanism
target
score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RHO 0.448
Identifier Residue Sequence Organism Cell Line
SIGNOR-253819 Homo sapiens HEK-293 Cell
pmid sentence
KLF15 repressed transactivation of rhodopsin and IRBP promoters alone and in combination with the transcriptional activators Crx and/or Nrl.
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RBP3 0.377
Identifier Residue Sequence Organism Cell Line
SIGNOR-253818 Homo sapiens HEK-293 Cell
pmid sentence
KLF15 repressed transactivation of rhodopsin and IRBP promoters alone and in combination with the transcriptional activators Crx and/or Nrl.
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NRL 0.556
Identifier Residue Sequence Organism Cell Line
SIGNOR-223796 Bos taurus
pmid sentence
Interaction of Fiz1 and NRL-leucine zipper was validated by GST pulldown assays and co-immunoprecipitation from bovine retinal nuclear extracts. Fiz1 suppressed NRL- but not CRX-mediated transactivation of rhodopsin promoter activity in transiently transfected CV1 cells.
Publications: 1 Organism: Bos Taurus
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