Summary

Name RHO
Full Name Rhodopsin
Synonyms Opsin-2 | OPN2
Primary ID P08100
Links - -
Type protein
Relations 15
Function Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation RHO 0.451
Publications: 6 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation RHO 0.922
Publications: 3 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RHO 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RHO 0.456
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RHO 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RHO 0.276
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAT1 0.785
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RHO 0.485
Publications: 1 Organism: Homo Sapiens