| + |
CDH4 | up-regulates activity 
|
RAC1 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253103 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18701479 |
Together, these data suggest that R-cadherin expression inhibits myogenesis and induces myoblast transformation through Rac1 activation. Therefore, the properties of R-cadherin make it an attractive target for therapeutic intervention in RMS. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DIAPH1 | up-regulates activity
|
CDH4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253110 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 22820501 |
Taken together, data obtained from MCF10A cells were consistent with the idea that Rho signaling to Dia1 and profilin-1 was essential for R-cadherin adherens junction formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PFN1 | up-regulates activity
|
CDH4 |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253111 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 22820501 |
Taken together, data obtained from MCF10A cells were consistent with the idea that Rho signaling to Dia1 and profilin-1 was essential for R-cadherin adherens junction formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH4 | up-regulates activity
binding
|
CTNNB1 |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21255999 |
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH4 | down-regulates quantity by repression 
|
CDH2 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253107 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 18701479 |
Taken together, these data show that (a) R-cadherin decreases the expression of M-cadherin and (b) N-cadherin and M-cadherin only slightly accumulate at the cell contacts in R-cadherin–expressing myoblasts. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CDH4 | down-regulates quantity by repression
|
CDH15 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253106 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 18701479 |
Taken together, these data show that (a) R-cadherin decreases the expression of M-cadherin and (b) N-cadherin and M-cadherin only slightly accumulate at the cell contacts in R-cadherin–expressing myoblasts. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
calcium(2+) | up-regulates activity
chemical activation
|
CDH4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265844 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22535893 |
Cadherins are Ca(2+)-dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDH4
- 
- 