3.0
Summary
| Name |  NPEPPS
|
| Full Name | Puromycin-sensitive aminopeptidase |
| Synonyms | PSA, EC 3.4.11.14, Cytosol alanyl aminopeptidase, AAP-S | PSA |
| Primary ID | P55786 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NPEPPS | up-regulates quantity 
chemical modification
|
peptide antigen | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NPEPPS | down-regulates quantity 
chemical modification
|
oligopeptide | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |