| + |
SP1 | up-regulates quantity by expression 
transcriptional regulation
|
GFER |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254450 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 18513187 |
We also confirmed that activation and repression of hHSS transcription induced by Sp1 and HNF4alpha resulted from binding of these factors to these two cis-elements respectively. Overexpression of HNF4alpha led to a dramatic repression of the promoter activity and, in contrast, the activity was markedly elevated by overexpression of Sp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | down-regulates quantity by repression 
transcriptional regulation
|
GFER |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253772 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 20690902 |
In the present study, we investigated transcription of hHSS triggered by EGF (epidermal growth factor) and the role of C/EBPβ (CCAAT/enhancer-binding protein β) as a potential core factor responsible for hHSS transcription in HepG2 cells. The results show that EGF suppresses hHSS mRNA expression at early time points. Using a promoter deletion assay, we identified a proximal region (-358/-212) that is required for EGF suppression. Overexpression of C/EBPβ enhances EGF suppression of hHSS, and mutation of the C/EBPβ-binding site at -292/-279 or siRNA (short interfering RNA) interference abolishes EGF suppression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | down-regulates quantity by repression
transcriptional regulation
|
GFER |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254449 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 18513187 |
We also confirmed that activation and repression of hHSS transcription induced by Sp1 and HNF4alpha resulted from binding of these factors to these two cis-elements respectively. Overexpression of HNF4alpha led to a dramatic repression of the promoter activity and, in contrast, the activity was markedly elevated by overexpression of Sp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GFER
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